Current Doyle Group Members

Soumen is from India and he obtained his Ph.D. from Indian Institute of Technology Indore under guidance of Dr. Sampak Samanta. His area of research was synthesis of biologically important heterocycles and enantioselective synthesis. After obtaining Ph.D., he joined Dr. Seunghoon Shin’s group at Hanyang University, Seoul as a postdoc where he was working on asymmetric dearomatization reactions. Then he moved to North Dakota State University to pursue his postdoc in Dr. Mukund Sibi’s group. He joined Dr. Doyle’s group at UTSA in July 2022. His current research in Doyle’s lab is to explore cycloaddition reactions of triazene N-oxides.

• Enantioselective Dearomative Cyclization of Homotryptamines with Allenamides into Indolo[2,3-b]quinolones; Soumen Biswas, Hanbyul Kim, Kiet Le Anh Cao, Seunghoon Shin. Adv. Synth. Catal. 2020, 362, 1841.
• β-Oxidation of Ynamides into N,O-Acetals by mCPBA: Application in Enantioselective Intermolecular Transacetalization; Nguyen H. Nguyen, Quynh H. Nguyen, Soumen Biswas, Dilip V. Patil, Seunghoon Shin. Org. Lett., 2019, 21, 9009-9013.
• Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's disease (HD) and spinocerebellar ataxia (SCAs); Eshan Khan, Soumen Biswas, Subodh K Mishra, Ribhav Mishra, Sampak Samanta, Amit Mishra, Arpita Tawani, Amit Kumar, Biochiemie, 2019, 163, 21-32.
• A Metal-and Solvent-Free Approach to Diversely Substituted Picolinates via Domino reaction of Cyclic Sulfamidate Imines with β,γ-Unsaturated α-Ketocarbonyls; Soumen Biswas, Debashis Majee, Soumitra Guin, Sampak Samanta. J. Org. Chem., 2017, 82, 10928-10938.
• Domino reaction of cyclic sulfamidate imines with Morita-Baylis-Hillman acetates promoted by DABCO: a metal-free approach to functionalized nicotinic acid derivatives; Debashis Majee, Soumen Biswas, Shaikh M. Mobin, Sampak Samanta. Org. Biomol. Chem., 2017, 15, 3286-3297.
• Access to 4,6-Diarylpicolinates via a Domino Reaction of Cyclic Sulfamidate Imines with Morita-Baylis-Hillman Acetates of Nitroolefins/Nitrodienes; Debashis Majee, Soumen Biswas, Shaikh M. Mobin, Sampak Samanta. J. Org. Chem., 2016, 81, 4378-4385.
• Access to Substituted Carbazoles in Water by a One-Pot Sequential Reaction of α,β-Substituted Nitro Olefins with 2-(3-Formyl-1H-indol-2-yl)acetates; Soumen Biswas, Anuradha Dagar, Anvita Srivastava, Sampak Samanta. Eur. J. Org. Chem., 2015, 4493-4503.

Marlyn is from Medellín, Colombia. In 2018, she joined to the Research Group of Chemistry of Colombian Plants, where she has worked on design and development of active compounds against Alzheimer’s disease under the supervision of Professor Andrés Felipe Yepes. She joined Dr. Doyle’s group as a visiting researcher in June of 2022.

• Yepes, A.F., Ramírez, C.A., Rada, M.S. et al. Discovery of novel donepezil-M30D hybrids with neuroprotective properties for Alzheimer’s disease treatment. Med Chem Res 31, 867–885 (2022).

Luca is from Rome, Italy; he joined UTSA in September 2016 and obtained his Master’s degree in inorganic chemistry with Dr. Ghezai Musie, working on sugar chiral recognition. In 2019, he joined Dr. Doyle’s group, where he has worked on selective oxidation, metal carbene, nitrosyl exchange and N-oxide projects. In 2021, he and his wife were blessed with the arrival of his son, Leonardo. In his spare time, Luca likes to spend time with his family, travel, teach, and make pizza for friends. In 2017, his teaching passion was recognized at UTSA with the Graduate Teaching Award.

• Su, Y.-L.; Liu, G.-X.; De Angelis, L.; He, R.; Al-Sayyed, A.; Schanze, K.; Hu, W.; Qiu, H.; Doyle, M.P. Radical Cascade Multicomponent Minisci Reactions with Diazo Compounds. ACS Catal. 2022, 12, 1357-1363.
• Zheng, H.; Wang, K.; De Angelis, L.; Hadi Arman, H.; Doyle, M.P. Brønsted Acid Catalyzed Oxocarbenium-olefin Metathe-sis/Rearrangements of 1H-isochromene Acetals with Vinyl Diazo Compounds. J. Am. Chem. Soc. 2021, 143, 15391–15399
• De Angelis, L.; Zheng, H.; Perz, M.; Arman, H.; Doyle, M.P. Intermolecular [5+1]-Cycloaddition between Vinyl Diazo Compounds and tert-Butyl Nitrite to 1,2,3-Triazine 1-Oxides and Their Further Transformation to Isoxazoles. Org. Lett. 2021, 23, 6542-6546.
• De Angelis, L.; Crawford, A. M.; Su, Y.-L.; Wherritt, D.; Arman, H.; Doyle, M.P. Catalyst-Free Formation of Nitrile Oxides and Their Further Transformations to Diverse Heterocycles. Org. Lett. 2021, 23, 925-929.
• Yongliang Su†, Luca De Angelis, Linh Tram, Yang Yu, Michael P. Doyle. Catalytic Oxidative Cleavage Reactions of Arylalkenes by tert-Butyl Hydroperoxide – A Mechanistic Assessment. J. Org. Chem. 2020, 85, 5, 3728–3741.
• Yongliang Su, Luca De Angelis, Michael P. Doyle. Discussion Addendum for: Allylic Oxidation Catalyzed by Dirhodium(II) Tetrakis[e-caprolactamate] of tert-Butyldimethylsilyl-protected trans-Dehydroandrosterone. Org. Synth. 2019, 96, 300-311.
• Marichev, K. O.; Dong, K.; Massey, L.A.; Deng, Y.; De Angelis, L.; Wang, K.; Arman, H.; Doyle, M.P. Chiral donor−acceptor azetines as powerful reactants for synthesis of amino acid derivatives. Nature Commun. 2019, 10, 5328.
• Leonelli, F., Mostarda, A., De Angelis, L., Lamba, D., Demitri, N., La Bella, A., Marini Bettolo, R. Proof of the structure of the stemodia chilensis tetracyclic diterpenoid (+)-19-acetoxystemodan-12-ol by synthesis from (+)-podocarpic acid: X-ray structure determination of a key intermediate. J. Nat. Prod, 2016, 79(4), 1155-1159.

Marriah is from Ashland, Ohio. She joined the research group because she wanted to gain more exposure in the laboratory and learn more chemistry outside of the classroom. In the short amount of time spent working with the group, she has grown an interest in pursuing a PhD in organic chemistry. Most of her spare time is spent taking care of her German shepherd puppy, Cal.

Louis was born in Houston, TX but moved to San Antonio, TX for a few years before finally moving to Laredo, TX where he finished his primary education before moving to San Antonio once again to attend UTSA where he is currently in pursuit of a B.S. and plans on going to Dental school following his graduation. He first encountered Organic Chemistry in 2019 and adores the subject and started working in Dr. Doyle’s Lab in 2022 to follow his passion. Outside of UTSA, Louis enjoys working and volunteering in dental clinics as a Dental Assistant, volunteers at Haven for Hope when he can, and spends the rest of his free time either studying or working out.

Alejandro is from Mission, Texas. He began his undergrad in 2018 which is when he began pursuing a Biology degree and hopes to get into Dental school. His favorite class so far has been organic chemistry, and his intent is to advance his knowledge in the lab to further his education in chemistry. In his free time, Alejandro likes to play tennis, listen to music, travel, and hike.