Research in the McCarrey lab is centered on mammalian germ cells and stem cells. Experimental models include the mouse, baboon, and human samples. We are interested in the epigenetic regulation of cell functions, including determination of cell fate, maintenance of genetic integrity, regulation of gene expression, and epigenomic reprogramming in the embryo and germ lines, including genomic imprinting. We are also interested in disruption of normal epigenetic programming (epimutations) caused by either methods of assisted reproduction, environmental exposures, or adverse lifestyles, and the potential for these induced epimutations to be transmitted to subsequent generations by transgenerational epigenetic inheritance. Finally we are interested in the evolution of tissue-specific gene expression in mammalian species, and developing the baboon as a model system for testing stem cell-based therapeutic applications.

Inquiries regarding opportunities for graduate student or postdoctoral positions can be addressed to john.mccarrey@utsa.edu.

 

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